Module Details
Module Code: |
ZPHA C2101 |
Module Title:
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Analytical Techniques Pharmaceutical Science
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Title:
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Analytical Techniques Pharmaceutical Science
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Module Level:: |
6 |
Module Coordinator: |
Paula Rankin
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Module Author:: |
Ariane Perez Gavilan
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Module Description: |
The aim of this module is to impart knowledge of basic analytical principles together with practical applications in pharmaceutical and related industries
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Learning Outcomes |
On successful completion of this module the learner will be able to: |
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Learning Outcome Description |
LO1 |
Explain and demonstrate a range of analytical techniques and discussthe theoretical background on which they are based. |
LO2 |
Operate analytical techniques used in the analysis of pharmaceuticals. |
LO3 |
Comprehend and apply quality control measures in pharmaceutical analysis. |
LO4 |
Carry out pharmaceutical assays and chromatographic separations of drugs. |
LO5 |
Identify certain categories of drugs. |
Dependencies |
Module Recommendations
This is prior learning (or a practical skill) that is recommended before enrolment in this module.
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No recommendations listed |
Co-requisite Modules
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No Co-requisite modules listed |
Additional Requisite Information
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No Co Requisites listed
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Indicative Content |
Analytical Techniques and Procedures
General approach to analytical procedures. Steps in analytical analysis. Representative sampling, sample preparation, analysis and interpretation of results. Systematic error and random error. Precision and accuracy. Measurement uncertainty.
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Titrimetric Methods:
Review of concentration calculations, ppm, w/w,w/v dilutions of solutions. Principles of titrations
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Spectroscopic Methods
Properties of light. Electromagnetic spectrum. Absorption of light. Beers Law. Absorption Spectra and colour. Spectrometer - good operating techniques. Applications of Beers' Law. Principles of atomic absorption and flame emission spectroscopy, sample treatment, use of standards. Interferences standard addition methods applications. Infra-red spectroscopy. Sample preparation. Identification of compounds using correlation charts
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Separation and Chromatographic Techniques
Separation and Chromatographic Techniques: Principles of adsorption, partition, ion exchange, molecular and affinity chromatography. Chromatogram description. Theoretical plates. Resolution selectivity. Gas-liquid chromatography. High performance liquid chromatography. Methods of separation. Mobile and stationary places. Columns detectors solvents. Sample preparation. Qualitative and quantitative measurements. Use in the analysis of drugs. Internal standards. Ion chromatography. Solvent extraction
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The Pharmaceutical industry
Introduction to pharmaceutical industry. Primary and secondary manufacture. Basic calculations in pharmaceutical analysis. Licensing of drugs and the pharmacopoeia. European Pharmacoipoeia, BP and USP monographs of pure drugs and formulations including assays, storage and identification.
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Pharmaceutical Chemistry
Selected categories of pharmaceuticals: vitamins, analgesics, general and local anaesthetics, sulphonamides antibiotics, antacids and acid-inhibitors, barbiturates.
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Analytical Techniques
Analytical methods used in drug analysis – UV/Vis, AAS, AES, Titrimetric, IR, GC and HPLC methods. E(1%,1cm). Dissolution testing.
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Chemistry of acids and bases
Ionisation of drugs. pKa values of drugs. Partition coefficients relating to drug absorption.
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Extraction Methods in Pharmaceutical analysis
Excipients in formulations. Solvent and solid phase extraction methods
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Control of the quality of analytical methods
Control of errors in analysis. Repeatability and reproducibility. Validation of drug analysis to include assay, precision specificity, LOD, LOQ, linearity, ruggedness and robustness.
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Practical
Practicals will develop skills in the use of analytical equipment and techniques from AAS, AES, FTIR, HPLC, GC, and UV-Vis and ion chromatography. The practicals covered will reinforce and amplify the material covered in the lecture course. The use of updated software will be implemented.
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Module Content & Assessment
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Assessment Breakdown | % |
Continuous Assessment | 60.00% |
Practical | 40.00% |
AssessmentsFull Time
No End of Module Formal Examination |
Reassessment Requirement |
Exam Board
It is at the discretion of the Examination Board as to what the qualifying criteria are.
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SETU Carlow Campus reserves the right to alter the nature and timings of assessment
Module Workload
Workload: Full Time |
Workload Type |
Workload Category |
Contact Type |
Workload Description |
Frequency |
Average Weekly Learner Workload |
Hours |
Lecture |
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Contact |
Analytical and pharmaceutical Principles |
12 Weeks per Stage |
4.00 |
48 |
Laboratory |
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Contact |
Analytical and pharmaceutical analysis |
12 Weeks per Stage |
4.00 |
48 |
Estimated Learner Hours |
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Non Contact |
Lecture notes and problem solving |
15 Weeks per Stage |
10.27 |
154 |
Total Weekly Contact Hours |
8.00 |
Module Resources
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Recommended Book Resources |
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Gary D. Christian, Purnendu K. Dasgupta, Kevin A. Schug. (2013), Analytical Chemistry, 7th. [ISBN: 9780470887].
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Daniel C. Harris; Charles A. Lucy. (2020), Quantitative Chemical Analysis, 10th. MacMillan, [ISBN: 9781319384807].
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David G. Watson. (2020), Pharmaceutical Analysis,A Textbook for Pharmacy Students and Pharmaceutical Chemists,3, 5th. Elsevier Health Sciences, p.427, [ISBN: 9780702078071].
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Donald Cairns.. (2012), Essentials of pharmaceutical chemistry, 4th. London; Pharmaceutical Press, [ISBN: 9780853699798].
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CHRIS. BARBER ROSTRON (JILL.),Chris (Honorary Research Fellow Rostron, Honorary Research Fellow Liverpool John Moores),Jill (Reader Barber, Reader The University of Manchester). (2021), Pharmaceutical Chemistry, 2nd. Oxford University Press, p.448, [ISBN: 9780198779780].
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Clarke's Isolation and Identification of Drugs, 2nd. The Pharmaceutical Press.
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European Directorate for the Quality of Medicines and Healthcare. European Pharmacopoeia, 10th edition.
| This module does not have any article/paper resources |
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Other Resources |
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