Module Details
Module Code: |
ZPHA C2102 |
Module Title:
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Pharmaceutical Science
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Title:
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Pharmaceutical Science
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Module Level:: |
6 |
Module Coordinator: |
Paula Rankin
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Module Author:: |
Ariane Perez Gavilan
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Module Description: |
To analyse and assay pharmaceutical formulations using different analytical techniques
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Learning Outcomes |
On successful completion of this module the learner will be able to: |
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Learning Outcome Description |
LO1 |
To carry out chromatographic separations of drugs, pharmaceutical assays, and to operate analytical techniques used in the analysis of pharmaceuticals. |
LO2 |
To identify certain categories of drugs. |
LO3 |
Comprehend and apply quality control measures in pharmaceutical analysis. |
Dependencies |
Module Recommendations
This is prior learning (or a practical skill) that is recommended before enrolment in this module.
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No recommendations listed |
Co-requisite Modules
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No Co-requisite modules listed |
Additional Requisite Information
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No Co Requisites listed
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Indicative Content |
Pharmaceutical industry
Introduction to pharmaceutical industry. Primary and secondary manufacture. Basic calculations in pharmaceutical analysis. Licensing of drugs and the pharmacopoeia. European Pharmacoipoeia, BP and USP monographs of pure drugs and formulations including assays, storage and identification.
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Pharmaceutical chemistry
Selected categories of pharmaceuticals: vitamins, analgesics, general and local anaesthetics, sulphonamides antibiotics, antacids and acid-inhibitors,
barbiturates.
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Control of the quality of analytical method
Control of errors in analysis. Repeatability and reproducibility. Validation of drug analysis to include assay, precision specificity, LOD, LOQ, linearity, ruggedness and robustness.
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Chemistry of acids and bases
Ionisation of drugs. pKa values of drugs. Partition coefficients relating to drug absorption.
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Analytical techniques
Analytical methods used in drug analysis – UV/Vis, AAS, AES, Titrimetric,IR, GC and HPLC methods. E(1%,1cm). Dissolution testing
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Extraction methods in pharmaceutical analysis
Excipients in formulations. Solvent and solid phase extraction methods.
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Chromatographic Techniques
Principles of adsorption, partition, ion exchange, molecular and affinity chromatography. Chromatogram description. Theoretical plates. Resolution, selectivity. Gas-liquid chromatography. High performance liquid chromatography. Methods of separation. Mobile and stationary phases. Columns, detectors, solvents. Use in the analysis of drugs. Sample preparation. Qualitative and quantitative measurements. Internal standards.
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Practical
Practicals will develop skills in the use of analytical equipment and techniques from AAS, AES, FTIR, HPLC, GC, UV-Vis in the analysis of selected pharmaceutical products. Specific assays from the BP or the EP will also be carried out.
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Module Content & Assessment
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Assessment Breakdown | % |
Continuous Assessment | 60.00% |
Practical | 40.00% |
AssessmentsFull Time
No End of Module Formal Examination |
Reassessment Requirement |
Exam Board
It is at the discretion of the Examination Board as to what the qualifying criteria are.
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Reassessment Description Students must achieve a minimum grade (35%) in both the practical and CA components
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SETU Carlow Campus reserves the right to alter the nature and timings of assessment
Module Workload
Workload: Full Time |
Workload Type |
Workload Category |
Contact Type |
Workload Description |
Frequency |
Average Weekly Learner Workload |
Hours |
Lecture |
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Contact |
Pharmaceutical terminology and problem solving |
12 Weeks per Stage |
2.00 |
24 |
Laboratory |
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Contact |
Analytical skills |
12 Weeks per Stage |
3.00 |
36 |
Estimated Learner Hours |
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Non Contact |
Familiarisation with all aspects of lectures and practicals |
15 Weeks per Stage |
4.33 |
65 |
Total Weekly Contact Hours |
5.00 |
Module Resources
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Recommended Book Resources |
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CHRIS. BARBER ROSTRON (JILL.),Chris (Honorary Research Fellow Rostron, Honorary Research Fellow Liverpool John Moores),Jill (Reader Barber, Reader The University of Manchester). (2021), Pharmaceutical Chemistry, 2nd. Oxford University Press, p.448, [ISBN: 9780198779780].
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David G. Watson. (2020), Pharmaceutical Analysis, 3rd. Elsevier, p.480, [ISBN: 9780702078071].
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Donald Cairns.. (2012), Essentials of pharmaceutical chemistry, 4th. London; Pharmaceutical Press, [ISBN: 9780853699798].
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British Pharmacopoeia Volume I & II.
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European Directorate for the Quality of Medicines and Healthcare. (2019), European Pharmacopoeia Volumes I, II, and III, 10th edition.
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Clarke's Isolation and Identification of Drugs, 2nd. The Pharmaceutical Press.
| This module does not have any article/paper resources |
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Other Resources |
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