Module Details

Module Code: ZPHA C2101
Module Title: Analytical Techniques Pharmaceutical Science
Title: Analytical Techniques Pharmaceutical Science
Module Level:: 6
Credits:: 10
Module Coordinator: Paula Rankin
Module Author:: Ariane Perez Gavilan
Domains:  
Module Description: The aim of this module is to impart knowledge of basic analytical principles together with practical applications in pharmaceutical and related industries
 
Learning Outcomes
On successful completion of this module the learner will be able to:
# Learning Outcome Description
LO1 Explain and demonstrate a range of analytical techniques and discussthe theoretical background on which they are based.
LO2 Operate analytical techniques used in the analysis of pharmaceuticals.
LO3 Comprehend and apply quality control measures in pharmaceutical analysis.
LO4 Carry out pharmaceutical assays and chromatographic separations of drugs.
LO5 Identify certain categories of drugs.
Dependencies
Module Recommendations

This is prior learning (or a practical skill) that is recommended before enrolment in this module.
No recommendations listed
Co-requisite Modules
No Co-requisite modules listed
Additional Requisite Information
No Co Requisites listed
 
Indicative Content
Analytical Techniques and Procedures
General approach to analytical procedures. Steps in analytical analysis. Representative sampling, sample preparation, analysis and interpretation of results. Systematic error and random error. Precision and accuracy. Measurement uncertainty.
Titrimetric Methods:
Review of concentration calculations, ppm, w/w,w/v dilutions of solutions. Principles of titrations
Spectroscopic Methods
Properties of light. Electromagnetic spectrum. Absorption of light. Beers Law. Absorption Spectra and colour. Spectrometer - good operating techniques. Applications of Beers' Law. Principles of atomic absorption and flame emission spectroscopy, sample treatment, use of standards. Interferences standard addition methods applications. Infra-red spectroscopy. Sample preparation. Identification of compounds using correlation charts
Separation and Chromatographic Techniques
Separation and Chromatographic Techniques: Principles of adsorption, partition, ion exchange, molecular and affinity chromatography. Chromatogram description. Theoretical plates. Resolution selectivity. Gas-liquid chromatography. High performance liquid chromatography. Methods of separation. Mobile and stationary places. Columns detectors solvents. Sample preparation. Qualitative and quantitative measurements. Use in the analysis of drugs. Internal standards. Ion chromatography. Solvent extraction
The Pharmaceutical industry
Introduction to pharmaceutical industry. Primary and secondary manufacture. Basic calculations in pharmaceutical analysis. Licensing of drugs and the pharmacopoeia. European Pharmacoipoeia, BP and USP monographs of pure drugs and formulations including assays, storage and identification.
Pharmaceutical Chemistry
Selected categories of pharmaceuticals: vitamins, analgesics, general and local anaesthetics, sulphonamides antibiotics, antacids and acid-inhibitors, barbiturates.
Analytical Techniques
Analytical methods used in drug analysis – UV/Vis, AAS, AES, Titrimetric, IR, GC and HPLC methods. E(1%,1cm). Dissolution testing.
Chemistry of acids and bases
Ionisation of drugs. pKa values of drugs. Partition coefficients relating to drug absorption.
Extraction Methods in Pharmaceutical analysis
Excipients in formulations. Solvent and solid phase extraction methods
Control of the quality of analytical methods
Control of errors in analysis. Repeatability and reproducibility. Validation of drug analysis to include assay, precision specificity, LOD, LOQ, linearity, ruggedness and robustness.
Practical
Practicals will develop skills in the use of analytical equipment and techniques from AAS, AES, FTIR, HPLC, GC, and UV-Vis and ion chromatography. The practicals covered will reinforce and amplify the material covered in the lecture course. The use of updated software will be implemented.
Module Content & Assessment
Assessment Breakdown%
Continuous Assessment60.00%
Practical40.00%

Assessments

Full Time

Continuous Assessment
Assessment Type Examination % of Total Mark 20
Timing n/a Learning Outcomes 1,5
Non-marked No
Assessment Description
written assessment examination
Assessment Type Examination % of Total Mark 20
Timing n/a Learning Outcomes 1,5
Non-marked No
Assessment Description
written assessment examination.
Assessment Type Examination % of Total Mark 20
Timing n/a Learning Outcomes 1,5
Non-marked No
Assessment Description
written assessment examination
No Project
Practical
Assessment Type Practical/Skills Evaluation % of Total Mark 40
Timing n/a Learning Outcomes 2,3,4
Non-marked No
Assessment Description
Laboratory worksheets and reports
Practical Log Book
No End of Module Formal Examination
Reassessment Requirement
Exam Board
It is at the discretion of the Examination Board as to what the qualifying criteria are.

SETU Carlow Campus reserves the right to alter the nature and timings of assessment

 

Module Workload

Workload: Full Time
Workload Type Workload Category Contact Type Workload Description Frequency Average Weekly Learner Workload Hours
Lecture Contact Analytical and pharmaceutical Principles 12 Weeks per Stage 4.00 48
Laboratory Contact Analytical and pharmaceutical analysis 12 Weeks per Stage 4.00 48
Estimated Learner Hours Non Contact Lecture notes and problem solving 15 Weeks per Stage 10.27 154
Total Weekly Contact Hours 8.00
 
Module Resources
Recommended Book Resources
  • Gary D. Christian, Purnendu K. Dasgupta, Kevin A. Schug. (2013), Analytical Chemistry, 7th. [ISBN: 9780470887].
  • Daniel C. Harris; Charles A. Lucy. (2020), Quantitative Chemical Analysis, 10th. MacMillan, [ISBN: 9781319384807].
  • David G. Watson. (2020), Pharmaceutical Analysis,A Textbook for Pharmacy Students and Pharmaceutical Chemists,3, 5th. Elsevier Health Sciences, p.427, [ISBN: 9780702078071].
  • Donald Cairns.. (2012), Essentials of pharmaceutical chemistry, 4th. London; Pharmaceutical Press, [ISBN: 9780853699798].
  • CHRIS. BARBER ROSTRON (JILL.),Chris (Honorary Research Fellow Rostron, Honorary Research Fellow Liverpool John Moores),Jill (Reader Barber, Reader The University of Manchester). (2021), Pharmaceutical Chemistry, 2nd. Oxford University Press, p.448, [ISBN: 9780198779780].
  • Clarke's Isolation and Identification of Drugs, 2nd. The Pharmaceutical Press.
  • European Directorate for the Quality of Medicines and Healthcare. European Pharmacopoeia, 10th edition.
This module does not have any article/paper resources
Other Resources
  • www.rsc.org.
Discussion Note: