Module Details

Module Code: ZPHA C2102
Module Title: Pharmaceutical Science
Title: Pharmaceutical Science
Module Level:: 6
Credits:: 5
Module Coordinator: Paula Rankin
Module Author:: Ariane Perez Gavilan
Domains:  
Module Description: To analyse and assay pharmaceutical formulations using different analytical techniques
 
Learning Outcomes
On successful completion of this module the learner will be able to:
# Learning Outcome Description
LO1 To carry out chromatographic separations of drugs, pharmaceutical assays, and to operate analytical techniques used in the analysis of pharmaceuticals.
LO2 To identify certain categories of drugs.
LO3 Comprehend and apply quality control measures in pharmaceutical analysis.
Dependencies
Module Recommendations

This is prior learning (or a practical skill) that is recommended before enrolment in this module.
No recommendations listed
Co-requisite Modules
No Co-requisite modules listed
Additional Requisite Information
No Co Requisites listed
 
Indicative Content
Pharmaceutical industry
Introduction to pharmaceutical industry. Primary and secondary manufacture. Basic calculations in pharmaceutical analysis. Licensing of drugs and the pharmacopoeia. European Pharmacoipoeia, BP and USP monographs of pure drugs and formulations including assays, storage and identification.
Pharmaceutical chemistry
Selected categories of pharmaceuticals: vitamins, analgesics, general and local anaesthetics, sulphonamides antibiotics, antacids and acid-inhibitors, barbiturates.
Control of the quality of analytical method
Control of errors in analysis. Repeatability and reproducibility. Validation of drug analysis to include assay, precision specificity, LOD, LOQ, linearity, ruggedness and robustness.
Chemistry of acids and bases
Ionisation of drugs. pKa values of drugs. Partition coefficients relating to drug absorption.
Analytical techniques
Analytical methods used in drug analysis – UV/Vis, AAS, AES, Titrimetric,IR, GC and HPLC methods. E(1%,1cm). Dissolution testing
Extraction methods in pharmaceutical analysis
Excipients in formulations. Solvent and solid phase extraction methods.
Chromatographic Techniques
Principles of adsorption, partition, ion exchange, molecular and affinity chromatography. Chromatogram description. Theoretical plates. Resolution, selectivity. Gas-liquid chromatography. High performance liquid chromatography. Methods of separation. Mobile and stationary phases. Columns, detectors, solvents. Use in the analysis of drugs. Sample preparation. Qualitative and quantitative measurements. Internal standards.
Practical
Practicals will develop skills in the use of analytical equipment and techniques from AAS, AES, FTIR, HPLC, GC, UV-Vis in the analysis of selected pharmaceutical products. Specific assays from the BP or the EP will also be carried out.
Module Content & Assessment
Assessment Breakdown%
Continuous Assessment60.00%
Practical40.00%

Assessments

Full Time

Continuous Assessment
Assessment Type Examination % of Total Mark 30
Timing n/a Learning Outcomes 1,2,3
Non-marked No
Assessment Description
Exam
Assessment Type Examination % of Total Mark 30
Timing n/a Learning Outcomes 1,2,3
Non-marked No
Assessment Description
Exam
No Project
Practical
Assessment Type Practical/Skills Evaluation % of Total Mark 40
Timing n/a Learning Outcomes 1
Non-marked No
Assessment Description
Lab Worksheets and Reports;
Practical Log Book
No End of Module Formal Examination
Reassessment Requirement
Exam Board
It is at the discretion of the Examination Board as to what the qualifying criteria are.
Reassessment Description
Students must achieve a minimum grade (35%) in both the practical and CA components

SETU Carlow Campus reserves the right to alter the nature and timings of assessment

 

Module Workload

Workload: Full Time
Workload Type Workload Category Contact Type Workload Description Frequency Average Weekly Learner Workload Hours
Lecture Contact Pharmaceutical terminology and problem solving 12 Weeks per Stage 2.00 24
Laboratory Contact Analytical skills 12 Weeks per Stage 3.00 36
Estimated Learner Hours Non Contact Familiarisation with all aspects of lectures and practicals 15 Weeks per Stage 4.33 65
Total Weekly Contact Hours 5.00
 
Module Resources
Recommended Book Resources
  • CHRIS. BARBER ROSTRON (JILL.),Chris (Honorary Research Fellow Rostron, Honorary Research Fellow Liverpool John Moores),Jill (Reader Barber, Reader The University of Manchester). (2021), Pharmaceutical Chemistry, 2nd. Oxford University Press, p.448, [ISBN: 9780198779780].
  • David G. Watson. (2020), Pharmaceutical Analysis, 3rd. Elsevier, p.480, [ISBN: 9780702078071].
  • Donald Cairns.. (2012), Essentials of pharmaceutical chemistry, 4th. London; Pharmaceutical Press, [ISBN: 9780853699798].
  • British Pharmacopoeia Volume I & II.
  • European Directorate for the Quality of Medicines and Healthcare. (2019), European Pharmacopoeia Volumes I, II, and III, 10th edition.
  • Clarke's Isolation and Identification of Drugs, 2nd. The Pharmaceutical Press.
This module does not have any article/paper resources
Other Resources
  • www.rsc.org.
Discussion Note: